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In a modern review, we described the identification plus the characterization of a brand new atypical opioid receptor with exceptional destructive regulatory Attributes toward opioid peptides.1 Our results showed that ACKR3/CXCR7, hitherto known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is also a broad-spectrum scavenger f